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1

The folate receptor: What does it promise in tissue-targeted therapeutics?

Marcela D’Alincourt Salazar, Manohar Ratnam

Journal:

Cancer and Metastasis Reviews

Year:

2007

Language:

english

File:

PDF, 240 KB

english, 2007

2

Practical synthesis of a chromene analog for use as a retinoic acid receptor alpha antagonist lead compound

Jetson, Rachael, Malik, Neha, Luniwal, Amarjit, Chari, Venkatesh, Ratnam, Manohar, Erhardt, Paul

Journal:

European Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 380 KB

english, 2013

3

Folate receptor type β is a neutrophilic lineage marker and is differentially expressed in myeloid leukemia

John F. Ross, Hui Wang, Frederick G. Behm, Prasad Mathew, Marietta Wu, Robert Booth, Manohar Ratnam

Journal:

Year:

1999

Language:

english

File:

PDF, 723 KB

english, 1999

4

Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications

John F. Ross, Prabir K. Chaudhuri, Manohar Ratnam

Journal:

Year:

1994

Language:

english

File:

PDF, 1.14 MB

english, 1994

5

Selective expression of folate receptor β and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis

Noriko Nakashima-Matsushita, Toshio Homma, Su Yu, Takemasa Matsuda, Nobuhiko Sunahara, Tadashi Nakamura, Michishi Tsukano, Manohar Ratnam, Takami Matsuyama

Journal:

Arthritis & Rheumatism

Year:

1999

Language:

english

File:

PDF, 249 KB

english, 1999

6

Folate receptor β as a potential delivery route for novel folate antagonists to macrophages in the synovial tissue of rheumatoid arthritis patients

Joost W. Van Der Heijden, Ruud Oerlemans, Ben A. C. Dijkmans, Huiling Qi, Conny J. Van Der Laken, Willem F. Lems, Ann L. Jackman, Maarten C. Kraan, Paul P. Tak, Manohar Ratnam, Gerrit Jansen

Journal:

Arthritis & Rheumatism

Year:

2009

Language:

english

File:

PDF, 220 KB

english, 2009

7

Targeting human clonogenic acute myelogenous leukemia cells via folate conjugated liposomes combined with receptor modulation by all-trans retinoic acid

Hong Li, Yanhui Lu, Longzhu Piao, Jun Wu, Shujun Liu, Guido Marcucci, Manohar Ratnam, Robert J. Lee

Journal:

International Journal of Pharmaceutics

Year:

2010

Language:

english

File:

PDF, 391 KB

english, 2010

8

Synthesis and biological evaluation of a new series of dihydrofolate reductase inhibitors based on the 4-(2,6-diamino-5-pyrimidinyl)alkyl-L-glutamic acid structure

Lynn S. Gossett, Lillian L. Habeck, Susan B. Gates, Sherri L. Andis, John F. Worzalla, Richard M. Schultz, Laurane G. Mendelsonn, William Kohler, Manohar Ratnam, Gerald B. Grindey, Chuan Shih

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 170 KB

english, 1996

9

Expression and sub-cellular localization of the CCAAT/enhancer binding protein α in relation to postnatal development and malignancy of the prostate

Juan Zhang, John Erby Wilkinson, Mesfin Gonit, Rick Keck, Steven Selman, Manohar Ratnam

Journal:

Year:

2008

Language:

english

File:

PDF, 1.24 MB

english, 2008

10

Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapy

Hala Elnakat, Manohar Ratnam

Journal:

Advanced Drug Delivery Reviews

Year:

2004

Language:

english

File:

PDF, 300 KB

english, 2004

11

The hydrophobic domains in the carboxyl-terminal signal for GPI modification and in the amino-terminal leader peptide have similar structural requirements

Wu Yan, Feng Shen, Bridget Dillon, Manohar Ratnam

Journal:

Journal of Molecular Biology

Year:

1998

Language:

english

File:

PDF, 398 KB

english, 1998

12

Anti-idiotypic antibodies elicited by pterin recognize active site epitopes in dihydrofolate reductases and dihydropteridine reductase

Shobha Ratnam, Manohar Ratnam, Richard G.H. Cotton, Ian G. Jennings, James H. Freisheim

Journal:

Archives of Biochemistry and Biophysics

Year:

1989

Language:

english

File:

PDF, 936 KB

english, 1989

13

Structural features of the nicotinic acetylcholine receptor revealed by antibodies to synthetic peptides

Manohar Ratnam, Jon Lindstrom

Journal:

Biochemical and Biophysical Research Communications

Year:

1984

Language:

english

File:

PDF, 990 KB

english, 1984

14

Differential stereospecificities and affinities of folate receptor isoforms for folate compounds and antifolates

Wang Xin, Shen Feng, James H. Freisheim, Larry E. Gentry, Manohar Ratnam

Journal:

Biochemical Pharmacology

Year:

1992

Language:

english

File:

PDF, 749 KB

english, 1992

15

Androgen activation of the folate receptor α gene through partial tethering of the androgen receptor by C/EBPα

Suneethi Sivakumaran, Juan Zhang, Karen M.M. Kelley, Mesfin Gonit, Hong Hao, Manohar Ratnam

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2010

Language:

english

File:

PDF, 529 KB

english, 2010

16

Dual regulation of ets-activated gene expression by SP1

Karen M.M. Kelley, Huiquan Wang1, Manohar Ratnam

Journal:

Year:

2003

Language:

english

File:

PDF, 527 KB

english, 2003

17

Recognition of the carboxyl-terminal signal for GPI modification requires translocation of its hydrophobic domain across the ER membrane

Jianyong Wang, Karen Maziarz, Manohar Ratnam

Journal:

Journal of Molecular Biology

Year:

1999

Language:

english

File:

PDF, 225 KB

english, 1999

18

Photoaffinity analogues of methotrexate as folate antagonist binding probes

James H. Freisheim, Manohar Ratnam, Philip L. Smith, Tavner J. Delcamp, Elmer M. Price

Journal:

Advances in Enzyme Regulation

Year:

1988

Language:

english

File:

PDF, 2.90 MB

english, 1988

19

Folate coenzyme and antifolate transport proteins in normal and neoplastic cells

James H. Freisheim, Elmer M. Price, Manohar Ratnam

Journal:

Advances in Enzyme Regulation

Year:

1989

Language:

english

File:

PDF, 876 KB

english, 1989

20

Molecular events in the membrane transport of methotrexate in human CCRF-CEM leukemia cell lines

James H. Freisheim, Manohar Ratnam, Terence P. McAlinden, K.M.R. Prasad, Frederick E. Williams, G. Robbin Westerhof, Jan H. Schornagel, Gerrit Jansen

Journal:

Advances in Enzyme Regulation

Year:

1992

Language:

english

File:

PDF, 1.42 MB

english, 1992

21

During hormone depletion or tamoxifen treatment of breast cancer cells the estrogen receptor apoprotein supports cell cycling through the retinoic acid receptor α1 apoprotein

Marcela D Salazar, Maya Ratnam, Mugdha Patki, Ivana Kisovic, Robert Trumbly, Mohamed Iman, Manohar Ratnam

Journal:

Breast Cancer Research

Year:

2011

Language:

english

File:

PDF, 2.52 MB

english, 2011

22

Using Monoclonal Antibodies to Determine the Structures of Acetylcholine Receptors from Electric Organs, Muscles, and Neurons

JON LINDSTROM, MANUEL CRIADO, MANOHAR RATNAM, PAUL WHITING, SCOTT RALSTON, JEAN RIVIER, VIRENDER SARIN, PETER SARGENT

Journal:

Annals of the New York Academy of Sciences

Year:

1987

Language:

english

File:

PDF, 1.50 MB

english, 1987

23

Analysis of Folate Binding Protein N-linked Glycans by Mass Spectrometry

Jaiswal, Nidhi, Saraswat, Suraj, Ratnam, Manohar, Isailovic, Dragan

Journal:

Journal of Proteome Research

Year:

2012

Language:

english

File:

PDF, 955 KB

english, 2012

24

Role of Formulation Composition in Folate Receptor-Targeted Liposomal Doxorubicin Delivery to Acute Myelogenous Leukemia Cells

Lu, Yanhui, Wu, Jun, Wu, Jianmei, Gonit, Mefsin, Yang, Xiaojuan, Lee, Alice, Xiang, Guangya, Li, Hong, Liu, Shujun, Marcucci, Guido, Ratnam, Manohar, Lee, Robert J.

Journal:

Molecular Pharmaceutics

Year:

2007

Language:

english

File:

PDF, 235 KB

english, 2007

25

Receptor induction and targeted drug delivery: a new antileukaemia strategy

Ratnam, Manohar, Hao, Hong, Zheng, Xuan, Wang, Hui, Qi, Huiling, Lee, Robert, Pan, Xing

Journal:

Expert Opinion on Biological Therapy

Year:

2003

Language:

english

File:

PDF, 238 KB

english, 2003

26

Proteolysis of the Carboxyl-Terminal GPI Signal Independent of GPI Modification as a Mechanism for Selective Protein Secretion †

Wang, Jianyong, Shen, Feng, Yan, Wu, Wu, Marietta, Ratnam, Manohar

Journal:

Year:

1997

Language:

english

File:

PDF, 213 KB

english, 1997

27

Characterization of the methotrexate transport pathway in murine L1210 leukemia cells: involvement of a membrane receptor and a cytosolic protein

Price, Elmer M., Ratnam, Manohar, Rodeman, Kevin M., Freisheim, James H.

Journal:

Year:

1988

Language:

english

File:

PDF, 3.38 MB

english, 1988

28

Comparison of solution structures of dihydrofolate reductases and enzyme-ligand complexes using cross-reacting antibodies

Ratnam, Manohar, Delcamp, Tavner J., Freisheim, James H.

Journal:

Year:

1986

Language:

english

File:

PDF, 896 KB

english, 1986

29

Transmembrane topography of the nicotinic acetylcholine receptor: immunochemical tests contadict theoretical predictions based on hydrophobicity profiles

Ratnam, Manohar, Nguyen Dung Le,, Rivier, Jean, Sargent, Peter B., Lindstrom, Jon

Journal:

Year:

1986

Language:

english

File:

PDF, 1.77 MB

english, 1986

30

Structural heterogeneity of the .alpha. subunits of the nicotinic acetylcholine receptor in relation to agonist affinity alkylation and antagonist binding

Ratnam, Manohar, Gullick, William, Spiess, Joachim, Wan, Kee, Criado, Manuel, Lindstrom, Jon

Journal:

Year:

1986

Language:

english

File:

PDF, 3.15 MB

english, 1986

31

Regulation of Folate Receptor Internalization by Protein Kinase C α

Elnakat, Hala, Gonit, Mesfin, D’Alincourt Salazar, Marcela, Zhang, Juan, Basrur, Venkatesha, Gunning, William, Kamen, Barton, Ratnam, Manohar

Journal:

Year:

2009

Language:

english

File:

PDF, 2.80 MB

english, 2009

32

Folate Receptor Type .gamma. Is Primarily a Secretory Protein Due to Lack of an Efficient Signal for Glycosylphosphatidylinositol Modification: Protein Characterization and Cell Type Specificity

Shen, Feng, Wu, Marietta, Ross, John F., Miller, Danielle, Ratnam, Manohar

Journal:

Year:

1995

Language:

english

File:

PDF, 1.60 MB

english, 1995

33

Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA

Ratnam, Manohar, Marquardt, Hans, Duhring, John L., Freisheim, James H.

Journal:

Year:

1989

Language:

english

File:

PDF, 1.49 MB

english, 1989

34

Variant GPI Structure in Relation to Membrane-Associated Functions of a Murine Folate Receptor †

Wang, Xin, Jansen, Gerrit, Fan, Jianguo, Kohler, William J., Ross, John F., Schornagel, Jan, Ratnam, Manohar

Journal:

Year:

1996

Language:

english

File:

PDF, 359 KB

english, 1996

35

Preferred Sites of Glycosylphosphatidylinositol Modification in Folate Receptors and Constraints in the Primary Structure of the Hydrophobic Portion of the Signal

Yan, Wu, Ratnam, Manohar

Journal:

Year:

1995

Language:

english

File:

PDF, 1.70 MB

english, 1995

36

Location of antigenic determinants of primary sequences of the subunits of nicotinic acetylcholine receptor by peptide mapping

Ratnam, Manohar, Sargent, Peter B., Sarin, Virender, Fox, J. Lawrence, Nguyen Dung Le,, Rivier, Jean, Criado, Manuel, Lindstrom, Jon

Journal:

Year:

1986

Language:

english

File:

PDF, 3.25 MB

english, 1986

37

Inhibition of murine thymidylate synthase and human dihydrofolate reductase by 5,8-dideaza analogs of folic acid and aminopterin

Hynes, John B., Patil, Shirish A., Tomazic, Alenka, Kumar, Arvind, Pathak, Alpana, Tan, Xuehai, Li, Xianqiang, Ratnam, Manohar, Delcamp, Tavner J., Freisheim, James H.

Journal:

Journal of Medicinal Chemistry

Year:

1988

Language:

english

File:

PDF, 873 KB

english, 1988

38

Identification of Amino Acid Residues that Determine the Differential Ligand Specificities of Folate Receptors α and β †

Shen, Feng, Zheng, Xuan, Wang, Jianyong, Ratnam, Manohar

Journal:

Year:

1997

Language:

english

File:

PDF, 168 KB

english, 1997

39

Ligand-induced structural constraints in human dihydrofolate reductase revealed by peptide-specific antibodies

Ratnam, Manohar, Tan, Xuehai, Prendergast, Neal J., Smith, Philip L., Freisheim, James H.

Journal:

Year:

1988

Language:

english

File:

PDF, 640 KB

english, 1988

40

The Interplay of AMP-Activated Protein Kinase and Androgen Receptor in Prostate Cancer Cells

Shen, Min, Zhang, Zhen, Ratnam, Manohar, Dou, Q. Ping

Journal:

Journal of Cellular Physiology

Year:

2014

Language:

english

File:

PDF, 1.26 MB

english, 2014

41

Differential effects of estrogen-dependent transactivation vs. transrepression by the estrogen receptor on invasiveness of HER2 overexpressing breast cancer cells

Patki, Mugdha, Salazar, Marcela d'alincourt, Trumbly, Robert, Ratnam, Manohar

Journal:

Biochemical and Biophysical Research Communications

Year:

2015

Language:

english

File:

PDF, 868 KB

english, 2015

42

Glucocorticoid Receptor Status Is a Principal Determinant of Variability in the Sensitivity of Non–Small-Cell Lung Cancer Cells to Pemetrexed

Patki, Mugdha, Gadgeel, Shirish, Huang, Yanfang, McFall, Thomas, Shields, Anthony F., Matherly, Larry H., Bepler, Gerold, Ratnam, Manohar

Journal:

Journal of Thoracic Oncology

Year:

2014

Language:

english

File:

PDF, 540 KB

english, 2014

43

R5020 and RU486 Act as Progesterone Receptor Agonists to Enhance Sp1/Sp4-Dependent Gene Transcription by an Indirect Mechanism

Shatnawi, Aymen, Tran, Thuyet, Ratnam, Manohar

Journal:

Molecular Endocrinology

Year:

2007

Language:

english

File:

PDF, 728 KB

english, 2007

44

Hormone Depletion-Insensitivity of Prostate Cancer Cells Is Supported by the AR Without Binding to Classical Response Elements

Gonit, Mesfin, Zhang, Juan, Salazar, Marcela d'Alincourt, Cui, Hongjuan, Shatnawi, Aymen, Trumbly, Robert, Ratnam, Manohar

Journal:

Molecular Endocrinology

Year:

2011

Language:

english

File:

PDF, 1.10 MB

english, 2011

45

Restoration of the cellular secretory milieu overrides androgen dependence of in vivo generated castration resistant prostate cancer cells overexpressing the androgen receptor

Patki, Mugdha, Huang, Yanfang, Ratnam, Manohar

Journal:

Biochemical and Biophysical Research Communications

Year:

2016

Language:

english

File:

PDF, 610 KB

english, 2016

46

Long-term treatment with dexamethasone induces senescence and progressive loss of proliferation potential in lung adenocarcinoma cells expressing high levels of the glucocorticoid receptor

Patki, Mugdha, Huang, Yanfang, Wilson, Mike, Fielder, Abby, Matherly, Larry, Polin, Lisa, Ratnam, Manohar

Journal:

Journal of Thoracic Oncology

Year:

2016

Language:

english

File:

PDF, 70 KB

english, 2016

47

HER2 status and disparities in luminal breast cancers

Holowatyj, Andreana N., Ruterbusch, Julie J., Ratnam, Manohar, Gorski, David H., Cote, Michele L.

Journal:

Cancer Medicine

Year:

2016

Language:

english

File:

PDF, 88 KB

english, 2016

48

Expression levels of functional folate receptors α and β are related to the number of N-glycosylated sites

SHEN, Feng, WANG, Huiquan, ZHENG, Xuan, RATNAM, Manohar

Journal:

Biochemical Journal

Year:

1997

Language:

english

File:

PDF, 406 KB

english, 1997

49

Use of monoclonal antibodies in exploring the structure of the acetylcholine receptor

LINDSTROM, JON, HOCHSCHWENDER, SUSAN, WAN, KEE, RATNAM, MANOHAR, CRIADO, MANUEL

Journal:

Biochemical Society Transactions

Year:

1985

Language:

english

File:

PDF, 421 KB

english, 1985

50

The Amino-terminal Domain of the Androgen Receptor Co-opts ERK Docking Sites in ELK1 to Induce Sustained Gene Activation that Supports Prostate Cancer Cell Growth

Rosati, Rayna, Patki, Mugdha, Chari, Venkatesh, Dakshnamurthy, Selvakumar, McFall, Thomas, Saxton, Janice, Kidder, Benjamin L, Shaw, Peter E., Ratnam, Manohar

Journal:

Journal of Biological Chemistry

Year:

2016

Language:

english

File:

PDF, 1.33 MB

english, 2016

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